Sickle cell disease
Sickle Cell Disease
Accurate and efficient genotype testing, and early detection can greatly improve the quality of life of patients living with sickle cell disease.
At biologix, we offer precise genotype testing which accurately detects even rare genotypes. We also test for sickle cell disease in newborns. Early detection will go a long way in ensuring proper management, alleviating suffering for patients and their families, and improving the overall quality of life of people living with sickle cell disease.
Sickle cell disorder is the most common inherited disorder in the world. About 75% (three quarters) of SCD cases occur in Africa. In Nigeria, it affects two out of every hundred children born, and causes suffering for innumerable patients and their families.
Sickle cell disorder is an inherited haemoglobin disorder made up of sickle cell anaemia (Hb SS) and some rare and less common but related conditions such as sickle haemoglobin C disorder (Hb SC) and sickle beta thalassaemia (Hb SBthal). The genes for these conditions arise by mutation but there was a rise in areas where there is or there was a high incidence of the most lethal strain of malaria known – falciparium malaria.
Despite its importance, there are very few dedicated sickle cell centers in Africa.
Lack of proper health education, shortage of sickle cell clinics, and limited research aimed at improving the environment of patients in the underprivileged situation of the world where sickle cell disease poses problems are restrictions to progress that can be made on SCD. Inaccurate diagnosis and genotype testing also contribute to limitations of SCD.
Prenatal Diagnosis and Newborn Screening for Sickle Cell Disorder
- A prenatal test can be done before a baby is born to detect if the baby is affected by sickle cell disorder or not. This is done through “DNA Analysing”. Using this method, it is possible to detect genes for haemoglobin A and haemoglobin S before the baby is born.
- A newborn screening is done by extracting some material from the baby just after the baby is born, and examining it through “DNA Analysis” to identify the nature of the genes thereby detecting if the baby is affected by sickle cell disorder or not.
Frequently Asked Questions
Yes, a person can have a blood test to find out if they have either sickle cell trait or a form of the disorder. There also are prenatal tests and newborn screening to find out if the baby will have the disorder or not. This procedure is available at Biologix Laboratories.
Yes, it is possible and this is called newborn screening. This is a service offered by Biologix Laboratories
No, sickle cell disorder is an inherited disease and is not contagious. To inherit the disease, a child must receive two (2) sickle cell genes, one (1) from each parent.
Lung tissue damage, pain episodes and stroke. The blockage of blood flow caused by sickled cells also causes damage to most organs including the spleen, liver and kidneys.
There is a 50 percent chance that a child born to parents who both carry a sickle cell gene will have the trait. There is a 25 percent chance that the child will have sickle cell disease. There also is a 25 percent chance that the child will have neither the trait nor the disease. These chances are the same in each pregnancy. If only one parent has the trait and the other has no abnormal hemoglobin gene, there is no chance that their children will have sickle cell disease. However, there is a 50-50 chance of each child having the trait.
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